{"id":6648,"date":"2023-01-09T06:33:00","date_gmt":"2023-01-09T06:33:00","guid":{"rendered":"https:\/\/tedxkarnavatiuniversity.com\/?p=6648"},"modified":"2023-01-11T15:33:52","modified_gmt":"2023-01-11T15:33:52","slug":"molnupiravir-me-efektiv-kunder-omicron-te-meshkujt-studimi-i-kafsheve-sugjeron","status":"publish","type":"post","link":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/2023\/01\/09\/molnupiravir-me-efektiv-kunder-omicron-te-meshkujt-studimi-i-kafsheve-sugjeron\/","title":{"rendered":"molnupiravir m\u00eb efektiv kund\u00ebr omicron te meshkujt, studimi i kafsh\u00ebve sugjeron"},"content":{"rendered":"<h1> molnupiravir m\u00eb efektiv kund\u00ebr omicron te meshkujt, studimi i kafsh\u00ebve sugjeron <\/h1>\n<ul>\n<li> Molnupiravir, nj\u00eb pilul\u00eb antivirale orale e autorizuar p\u00ebr t\u00eb trajtuar covid-19, ka qen\u00eb n\u00eb dispozicion n\u00eb Shtetet e Bashkuara dhe vendet e tjera q\u00eb nga dhjetori 2021 . <\/li>\n<li> Hulumtimi i ri i kafsh\u00ebve sugjeron q\u00eb Molnupiravir mund t\u00eb funksionoj\u00eb m\u00eb mir\u00eb p\u00ebr seksin mashkull me infeksione omicron. <\/li>\n<li> Ekspert\u00ebt thon\u00eb se modelet e kafsh\u00ebve mund t\u00eb p\u00ebrdoren p\u00ebr t\u00eb testuar efektivitetin e drog\u00ebs n\u00eb variante t\u00eb ndryshme, p\u00ebrfshir\u00eb Omicron, n\u00eb provat paraklinike.<!--more--> <\/li>\n<\/ul>\n<p> T\u00eb gjitha t\u00eb dh\u00ebnat dhe statistikat bazohen n\u00eb t\u00eb dh\u00ebnat n\u00eb dispozicion t\u00eb publikut n\u00eb koh\u00ebn e publikimit. Disa informacione mund t\u00eb jen\u00eb t\u00eb vjetra. Vizitoni qendr\u00ebn ton\u00eb t\u00eb koronavirusit p\u00ebr informacionin m\u00eb t\u00eb fundit mbi pandemin\u00eb COVID-19. <\/p>\n<p> Nd\u00ebrsa vaksinat COVID-19 kan\u00eb qen\u00eb thelb\u00ebsore p\u00ebr t\u00eb ndihmuar n\u00eb uljen e numrit t\u00eb vdekjeve t\u00eb shkaktuara nga infeksionet SARS-COV-2, antiviral\u00ebt gjithashtu luajt\u00ebn nj\u00eb rol. <\/p>\n<p> Nj\u00eb nga ato ila\u00e7e \u00ebsht\u00eb molnupiravir, i cili ushqimi &amp; amp; Administrata e Drog\u00ebs (FDA) e autorizuar p\u00ebr p\u00ebrdorim te njer\u00ebzit mbi mosh\u00ebn 1 vje\u00e7 n\u00eb dhjetor 2021. Ka qen\u00eb nj\u00eb ila\u00e7 ve\u00e7an\u00ebrisht i dobish\u00ebm pasi mund t\u00eb merret me goj\u00eb dhe n\u00eb sht\u00ebpi n\u00eb nj\u00eb p\u00ebrpjekje p\u00ebr t\u00eb shmangur shtrimin n\u00eb spital. <\/p>\n<p> Hulumtimi i botuar n\u00eb tetor 2021 n\u00eb tregimin se Molnupiravir uli rrezikun e shtrimit n\u00eb spital me 50% n\u00eb njer\u00ebzit n\u00eb rrezik m\u00eb t\u00eb lart\u00eb t\u00eb COVID-19 t\u00eb r\u00ebnd\u00eb. <\/p>\n<p> Nj\u00eb grup shum\u00eb-qendror i hetuesve t\u00eb kryesuar nga nj\u00eb ekip n\u00eb Universitetin Shtet\u00ebror t\u00eb Xhorxhis\u00eb hetoi efektin e molnupiravir n\u00eb variante t\u00eb ndryshme t\u00eb shqet\u00ebsimit SARS-COV-2, p\u00ebrfshir\u00eb Alpha, Beta, Gamma, Delta, dhe Omicron, N\u00eb qelizat njer\u00ebzore, organoidet e rrjedhura nga qelizat njer\u00ebzore, ferre dhe hamsters xhuxh, me disa rezultate t\u00eb p\u00ebrziera. <\/p>\n<p> Studiuesit publikuan rezultatet n\u00eb Komunikimet e Natyr\u00ebs. <\/p>\n<h2> molnupiravir p\u00ebr covid-19 <\/h2>\n<p> siguria dhe efektiviteti. Studiuesit <\/p>\n<p> kishin dokumentuar mir\u00eb aft\u00ebsit\u00eb e evazionit imunitar t\u00eb varianteve t\u00eb reja SARS-COV-2-n\u00ebse ishte imuniteti i fituar p\u00ebrmes vaksinimit ose infeksionit t\u00eb m\u00ebparsh\u00ebm. Sidoqoft\u00eb, \u00ebsht\u00eb e paqart\u00eb se si variantet ndikojn\u00eb n\u00eb efektivitetin e trajtimeve antivirale t\u00eb ila\u00e7eve si\u00e7 \u00ebsht\u00eb molnupiravir. &gt; Zyrtar Shkencor n\u00eb Imunik Therapeutics. <\/p>\n<p> Kjo qasje e bazuar n\u00eb host, si\u00e7 \u00ebsht\u00eb hartimi i ila\u00e7eve q\u00eb mund t\u00eb ken\u00eb nj\u00eb efekt antiviral n\u00eb qeliz\u00ebn prit\u00ebse sesa n\u00eb virus, mund t\u00eb ndihmoj\u00eb n\u00eb zhvillimin e trajtimeve kund\u00ebr variacioneve t\u00eb ardhshme. <\/p>\n<p> Dr. Kohlhof i tha lajmeve mjek\u00ebsore sot n\u00eb nj\u00eb intervist\u00eb se Molnupiravir \u00ebsht\u00eb nj\u00eb antiviral me baz\u00eb relativisht t\u00eb gjer\u00eb do t\u00eb thot\u00eb q\u00eb efikasiteti i tij nuk duhet t\u00eb-n\u00eb teori-ndryshon midis varianteve t\u00eb ndryshme aq sa vaksinat, t\u00eb cilat ishin krijuar vet\u00ebm p\u00ebr t\u00eb Synoni protein\u00ebn e pik\u00ebs. <\/p>\n<p> &quot;Vaksinimi, t\u00eb jet\u00eb me t\u00eb v\u00ebrtet\u00eb efikas, duhet t\u00eb jet\u00eb sa m\u00eb specifik q\u00eb t\u00eb jet\u00eb e mundur n\u00eb proteina t\u00eb caktuara nga virusi. Dhe n\u00ebse b\u00ebni zhvillimin e ila\u00e7eve antivirale, dhe n\u00ebse keni k\u00ebt\u00eb qasje t\u00eb bazuar n\u00eb host, me t\u00eb v\u00ebrtet\u00eb po veproni n\u00eb nj\u00eb mekaniz\u00ebm brenda qeliz\u00ebs s\u00eb infektuar dhe jo n\u00eb virus direkt, &quot;shpjegoi Dr. Kohlhof. <\/p>\n<p> Nuk \u00ebsht\u00eb e leht\u00eb t\u00eb mbash prova klinike p\u00ebr secilin variant t\u00eb ri pasi k\u00ebto marrin muaj. P\u00ebr m\u00eb tep\u00ebr, nj\u00eb variant i ri mund t\u00eb b\u00ebhet mbizot\u00ebrues kur publikohen rezultatet. Kjo \u00ebsht\u00eb arsyeja pse ajo ka nxitur shkenc\u00ebtar\u00ebt q\u00eb t\u00eb zhvillojn\u00eb modele t\u00eb tjera, si\u00e7 jan\u00eb qelizat njer\u00ebzore ose kafsh\u00ebt, p\u00ebr t\u00eb provuar efektin e k\u00ebtyre terapive antivirale p\u00ebr COVID-19. <\/p>\n<p> Organizata Bot\u00ebrore e Sh\u00ebndetit, p\u00ebr shembull, mblodhi grupin e saj t\u00eb ekspert\u00ebve t\u00eb modelimit COVID-19 n\u00eb vitin 2020. Grupi vler\u00ebson p\u00ebrparimet n\u00eb modelet e kafsh\u00ebve t\u00eb p\u00ebrdorura si modele preklinike. Deri m\u00eb tani, ekspert\u00ebt kan\u00eb propozuar primat\u00ebt, minjt\u00eb, ferret dhe hamsters jo njer\u00ebzor\u00eb si modele potencialisht t\u00eb dobishme. <\/p>\n<p> Dr. Simon Funnell, nj\u00eb udh\u00ebheq\u00ebs shkencor i Agjencis\u00eb s\u00eb Siguris\u00eb Sh\u00ebndet\u00ebsore n\u00eb Sh.B.A dhe nj\u00eb an\u00ebtar i grupit t\u00eb ekspert\u00ebve t\u00eb OBSH -s\u00eb p\u00ebr dy vitet e fundit, i tha MNT se nj\u00eb nga rezultatet e k\u00ebsaj pune ishte t\u00eb nxjerr\u00eb n\u00eb pah r\u00ebnd\u00ebsin\u00eb t\u00eb riprodhimit t\u00eb gjetjeve t\u00eb tilla n\u00eb m\u00eb shum\u00eb se nj\u00eb specie. <\/p>\n<p> &quot;P\u00ebrvoja ka treguar, ve\u00e7an\u00ebrisht gjat\u00eb pandemis\u00eb SARS-COV-2, se ekziston nj\u00eb forc\u00eb e madhe n\u00eb ndarjen dhe verifikimin e t\u00eb dh\u00ebnave nga grupe t\u00eb pavarura,&quot; tha Dr. Funnell. <\/p>\n<p> Ai dha nj\u00eb shembull se si p\u00ebrparoi hulumtimi rreth hidroksilorit p\u00ebr covid-19. <\/p>\n<p> &quot;Ky ishte rasti p\u00ebr vler\u00ebsimin paraklinik t\u00eb hidroksilkorit, ku gjetjet e kultur\u00ebs s\u00eb organeve t\u00eb njeriut u mb\u00ebshtet\u00ebn nga t\u00eb dh\u00ebna jo-njer\u00ebzore t\u00eb modelit t\u00eb kafsh\u00ebve dhe t\u00eb tjera t\u00eb modelit t\u00eb kafsh\u00ebve [q\u00eb treguan se nuk ishte nj\u00eb ila\u00e7 efektiv] pavar\u00ebsisht gjetjeve t\u00eb hershme n\u00eb Vero Qelizat dhe minjt\u00eb q\u00eb sugjeruan se do t\u00eb ishte nj\u00eb ila\u00e7 i dobish\u00ebm p\u00ebr t\u00eb trajtuar infeksionin SARS-COV-2, &quot;shpjegoi ai. <\/p>\n<h2> Testimi i molnupiravir n\u00eb modele t\u00eb ndryshme <\/h2>\n<p> P\u00ebr eksperimentin e tyre t\u00eb par\u00eb, studiuesit shikuan efektin e drog\u00ebs n\u00eb qelizat njer\u00ebzore t\u00eb infektuara me variante t\u00eb ndryshme shqet\u00ebsimi. P\u00ebr ta b\u00ebr\u00eb k\u00ebt\u00eb, ata shikuan qelizat in vitro dhe zhvilluan organoide t\u00eb dizajnuara p\u00ebr t\u00eb sjell\u00eb si organe miniatur\u00eb t\u00eb b\u00ebra nga inde q\u00eb rrjedhin nga linjat e qelizave njer\u00ebzore. <\/p>\n<p> Si pjes\u00eb e k\u00ebtij eksperimenti, studiuesit zhvilluan organoide p\u00ebr t\u00eb imituar epitelin e mushk\u00ebrive te njer\u00ebzit, duke p\u00ebrdorur qeliza nga nj\u00eb donator njer\u00ebzor mashkull. Analiza e tyre zbuloi se molnupiravir penguan n\u00eb m\u00ebnyr\u00eb t\u00eb barabart\u00eb variantet e shqet\u00ebsimit n\u00eb qeliza dhe organoide. <\/p>\n<p> Ata kryen studime t\u00eb m\u00ebtejshme n\u00eb ferre, t\u00eb cilat treguan se trajtimi i molnupiravir zvog\u00ebloi derdhjen e virusit dhe parandaloi transmetimin. <\/p>\n<h2> Dallimet seksuale me omicron <\/h2>\n<p> Sidoqoft\u00eb, nj\u00eb nga gjetjet m\u00eb befasuese nga studimi ishte kur hamsters mashkull xhuxh u mundua m\u00eb mir\u00eb n\u00eb p\u00ebrgjith\u00ebsi sesa hamsters femra kur trajtohej me molnupiravir pas infeksionit me Omicron. Studiuesit nuk e v\u00ebzhguan k\u00ebt\u00eb ndryshim me variantet e tjera, t\u00eb cilat p\u00ebrputhen me provat e m\u00ebparshme te njer\u00ebzit. <\/p>\n<p> <a href=\"https:\/\/harmoniqhealth.com\/al\/\">harmoniqhealth.com<\/a> Studimi nuk hetoi ndikimin e seksit n\u00eb rezultatet n\u00eb modelet e tjera pasi ferret e vetme t\u00eb p\u00ebrdorura ishin femra dhe qelizat e p\u00ebrdorura p\u00ebr t\u00eb zhvilluar organoide ishin meshkuj. <\/p>\n<p> Dr. Funnell tha q\u00eb kjo mund t\u00eb ishte hetuar m\u00eb tej: <\/p>\n<p> \u201cDonator\u00ebt femra njer\u00ebzore jan\u00eb n\u00eb dispozicion p\u00ebr kultur\u00ebn organoide dhe duket se kjo leht\u00eb mund t\u00eb hetohet. Media e p\u00ebrdorur p\u00ebr studime t\u00eb tilla gjithashtu mund t\u00eb jet\u00eb e ekuilibruar p\u00ebr t\u00eb pasqyruar ndryshimet hormonale njer\u00ebzore n\u00eb qarkullimin e gjakut. &quot; <\/p>\n<h2> m\u00eb shum\u00eb k\u00ebrkime t\u00eb nevojshme <\/h2>\n<p> Dr. Funnell gjithashtu theksoi nj\u00eb tjet\u00ebr kufizim t\u00eb gjetjeve. Hamsters xhuxh t\u00eb p\u00ebrdorur n\u00eb eksperimente ishin midis 3 dhe 10 muajsh, gj\u00eb q\u00eb mund t\u00eb jet\u00eb ndryshimi midis nj\u00eb f\u00ebmije dhe nj\u00eb t\u00eb rritur, ai i tha MNT. <\/p>\n<p> \u201cBket\u00ebsia e xhuxhit e cituar n\u00eb k\u00ebt\u00eb studim karakterizohet m\u00eb pak dhe p\u00ebrfaq\u00ebson nj\u00eb model relativisht t\u00eb ri t\u00eb SARS-COV-2. Nj\u00eb ve\u00e7anti e qart\u00eb e k\u00ebtij modeli \u00ebsht\u00eb patogjeniteti i duksh\u00ebm i rritur i variantit t\u00eb delta t\u00eb SARS-COV-2, &quot;tha ai. <\/p>\n<p> \u201cKjo virulenc\u00eb e p\u00ebrmir\u00ebsuar jasht\u00ebzakonisht e variantit t\u00eb delt\u00ebs nuk mund t\u00eb shpjegohet aktualisht. Do t\u00eb ishte e men\u00e7ur t\u00eb mos ekstrapoloni vaksinat ose efikasitetin terapeutik n\u00eb k\u00ebt\u00eb model me k\u00ebt\u00eb variant derisa t\u00eb kuptohet plot\u00ebsisht kjo virulenc\u00eb e p\u00ebrmir\u00ebsuar jasht\u00ebzakonisht, &quot;shpjegoi Dr. Funnell. <\/p>\n<ul>\n<li> S\u00ebmundjet infektive\/bakteret\/viruset <\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>molnupiravir m\u00eb efektiv kund\u00ebr omicron te meshkujt, studimi i kafsh\u00ebve sugjeron Molnupiravir, nj\u00eb pilul\u00eb antivirale orale e autorizuar p\u00ebr t\u00eb trajtuar covid-19, ka qen\u00eb n\u00eb dispozicion n\u00eb Shtetet e Bashkuara dhe vendet e tjera q\u00eb nga dhjetori 2021 . Hulumtimi [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[91],"tags":[],"_links":{"self":[{"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/posts\/6648"}],"collection":[{"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/comments?post=6648"}],"version-history":[{"count":1,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/posts\/6648\/revisions"}],"predecessor-version":[{"id":6649,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/posts\/6648\/revisions\/6649"}],"wp:attachment":[{"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/media?parent=6648"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/categories?post=6648"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tedxkarnavatiuniversity.com\/index.php\/wp-json\/wp\/v2\/tags?post=6648"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}